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Adults with persisting ADHD thus may represent a subgroup with symptoms caused by other neurobiological underpinnings than a mere delay of cortical development.

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We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups.

Results: The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text Lesage, A., and Steckler, T. Metabotropic glutamate m Glu1 receptor stimulation and blockade: therapeutic opportunities in psychiatric illness.

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We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults with ADHD and healthy controls. Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text Ludolph, A.

Methods: Twenty-nine adults with ADHD and 38 healthy controls were included.

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